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. 2014 Mar 24;19(3):3820-31.
doi: 10.3390/molecules19033820.

Goat milk fat naturally enriched with conjugated linoleic acid increased lipoproteins and reduced triacylglycerol in rats

Raphaela Rodrigues  1 , Juliana Soares  2 , Hugo Garcia  3 , Claudenice Nascimento  4 , Maria Medeiros  5 , Marco Bomfim  6 , Maria Carmo Medeiros  7 , Rita Queiroga  8
Affiliations

Goat milk fat naturally enriched with conjugated linoleic acid increased lipoproteins and reduced triacylglycerol in rats

Raphaela Rodrigues et al. Molecules. .

Abstract

Goat milk is source of different lipids, including conjugated linoleic acid (CLA). CLA reduces body fat and protect against cardiovascular diseases. In the present study fat from goat milk naturally enriched with CLA was used. Male Wistar rats were divided into three groups that received during a 10 week diet with different lipid sources: soybean oil (CON), coconut oil (CO) and goat milk fat naturally enriched with CLA (GM-CLA). We evaluated the effects of a GM-CLA on biochemistry parameters--high density lipoprotein (HDL), triacylglycerol (TAG), TAG/HDL ratio, total cholesterol and glucose, body weight and histopathological aspects of the intestine and liver. GM-CLA increased body weight from the second to the fifth week of the experiment compared to CON. Feed intake differed between the CON group and GM-CLA early in the first to third week of the experiments and later between the ninth and tenth week. The CLA-diet group showed increased levels of HDL, reduced levels of TAG and TAG/HDL ratio and no effect on LDL, but enhanced total cholesterol. Serum glucose of the GM-CLA group showed no difference from the control group. Thus, a GM-CLA diet promoted growth in young rats and acted as protector of cardiovascular function, but further studies are still needed to clarify these effects.

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Conflict of interest statement

The authors have declared no conflict of interest.

Figures

Figure 1
Figure 1
Body weight (g) for each week of experimental treatment (means ± sd). The number of animals in the groups is 12. An (*) denotes a significant difference (p ≤ 0.05) from control group. An (#) denotes a significant difference (p ≤ 0.05) from control and coconut groups.
Figure 2
Figure 2
Weekly means of food intake for each experimental group. The number of animals in the groups is 12. An (*) denotes a significant difference (p ≤ 0.05) from control group. An (#) denotes a significant difference (p ≤ 0.05) from control and coconut groups.
Figure 3
Figure 3
Histological sections of rat’s liver from the experimental groups: GM-CLA (A) CO (B) and CON (C). Arrows indicates fat accumulations on liver cells, characteristic of hepatic steatosis. Scale bar = 10 μm.
See this image and copyright information in PMC

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