Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2014 May;15(5):293-306.
doi: 10.1038/nrg3724. Epub 2014 Mar 25.

Gene expression regulation mediated through reversible m⁶A RNA methylation

Ye Fu  1 , Dan Dominissini  2 , Gideon Rechavi  3 , Chuan He  1
Affiliations
Review

Gene expression regulation mediated through reversible m⁶A RNA methylation

Ye Fu et al. Nat Rev Genet. 2014 May.

Abstract

Cellular RNAs carry diverse chemical modifications that used to be regarded as static and having minor roles in 'fine-tuning' structural and functional properties of RNAs. In this Review, we focus on reversible methylation through the most prevalent mammalian mRNA internal modification, N(6)-methyladenosine (m(6)A). Recent studies have discovered protein 'writers', 'erasers' and 'readers' of this RNA chemical mark, as well as its dynamic deposition on mRNA and other types of nuclear RNA. These findings strongly indicate dynamic regulatory roles that are analogous to the well-known reversible epigenetic modifications of DNA and histone proteins. This reversible RNA methylation adds a new dimension to the developing picture of post-transcriptional regulation of gene expression.

PubMed Disclaimer

References

    1. Science. 2001 Dec 7;294(5549):2113-5 - PubMed
    1. Immunity. 2005 Aug;23(2):165-75 - PubMed
    1. Mol Cell. 2011 Aug 5;43(3):327-39 - PubMed
    1. J Mol Evol. 2008 Jan;66(1):80-4 - PubMed
    1. Nat Rev Genet. 2008 Sep;9(9):699-712 - PubMed

Publication types

LinkOut - more resources