Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2014 Mar 24;9(3):e92623.
doi: 10.1371/journal.pone.0092623. eCollection 2014.

Diabetes and risk of tuberculosis relapse: nationwide nested case-control study

Pin-Hui Lee  1 , Hui-Chen Lin  2 , Angela Song-En Huang  2 , Sung-Hsi Wei  3 , Mei-Shu Lai  4 , Hsien-Ho Lin  4
Affiliations

Diabetes and risk of tuberculosis relapse: nationwide nested case-control study

Pin-Hui Lee et al. PLoS One. .

Abstract

The aim of this study was to investigate the association between diabetes mellitus (DM) and tuberculosis (TB) relapse using the nationwide TB registry in Taiwan. We conducted a case-control study nested within a nationwide cohort of all incident cases of pulmonary TB that were notified during 2006-2007 and had completed anti-TB treatment. The relapse of TB was confirmed by bacteriological or pathological findings. For each relapse case, one control was selected from the study cohort matching by time since treatment completion. DM status was ascertained by medical chart review and cross-matching with the National Health Insurance claims database. A total of 305 cases of relapse were identified after a median follow-up of 3 years (relapse rate: 488 per 100,000 person-year; 95% confidence interval (CI): 434-546). Presence of DM during previous anti-TB treatment was 34.0% and 22.7% in cases and controls, respectively. After adjusting for other potential confounders, DM was associated with increased risk of TB relapse (adjusted odds ratio: 1.96, 95% CI: 1.22-3.15). Only one-third of the DM-TB patients in our study received glycaemic monitoring using HbA1c during anti-TB treatment. Presence of DM was independently associated with risk of TB relapse. TB programs should seriously consider rigorous glucose control in DM-TB patients.

PubMed Disclaimer

Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Flow diagram for the enrollment of study participants in the nested case-control study.
Figure 2
Figure 2. Adjusted odds ratio for the association between DM and TB relapse, by age-group and follow-up period.
See this image and copyright information in PMC

References

    1. WHO (2012) Global Tuberculosis report 2012. World Health Organisation.
    1. Crofts JP, Andrews NJ, Barker RD, Delpech V, Abubakar I (2010) Risk factors for recurrent tuberculosis in England and Wales, 1998-2005. Thorax 65: 310–314. - PubMed
    1. WHO (2010) Multidrug and extensively drug-resistant TB (M/XDR-TB): 2010 global report on surveillance and response. World Health Organization.
    1. Murray J, Sonnenberg P, Shearer SC, Godfrey-Faussett P (1999) Human immunodeficiency virus and the outcome of treatment for new and recurrent pulmonary tuberculosis in African patients. Am J Respir Crit Care Med 159: 733–740. - PubMed
    1. Goldhaber-Fiebert JD, Jeon CY, Cohen T, Murray MB (2011) Diabetes mellitus and tuberculosis in countries with high tuberculosis burdens: individual risks and social determinants. Int J Epidemiol 40: 417–428. - PMC - PubMed

Publication types