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Review
. 2014 Apr;19(4):367-74.
doi: 10.1634/theoncologist.2013-0178. Epub 2014 Mar 24.

Management of localized esophageal cancer in the older patient

Elizabeth Won  1 , David H Ilson
Affiliations
Review

Management of localized esophageal cancer in the older patient

Elizabeth Won et al. Oncologist. 2014 Apr.

Abstract

Most patients with gastroesophageal cancers are older than 65 years of age. The management of older patients poses challenges because they have multiple comorbidities and physiological changes associated with aging. Furthermore, data are limited on tolerance of cancer therapy and the use of combined-modality treatments in this patient population to guide their treatment. In this article, we focus on the management of older patients with localized esophageal cancer, highlighting the role of comprehensive geriatric assessment to identify and better tailor treatment approaches in this patient population. We review the literature and discuss the role of surgical resection and potential complications specific to an older patient. We review the rationale of combined-modality treatment and the potential benefits of a chemoradiotherapy-based approach in this patient population.

Keywords: Chemoradiotherapy; Elderly; Esophageal cancer; Geriatric oncology.

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Conflict of interest statement

Disclosures of potential conflicts of interest may be found at the end of this article.

Figures

Figure 1.
Figure 1.
Management algorithm for localized esophageal cancer. *, Preferred regimen. Abbreviation: 5-FU, 5-fluorouracil.
See this image and copyright information in PMC

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