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Randomized Controlled Trial
. 2015 Mar;70(3):288-90.
doi: 10.1136/thoraxjnl-2014-205127. Epub 2014 Mar 24.

Bronchoscopic lung volume reduction with endobronchial valves for patients with heterogeneous emphysema and intact interlobar fissures (the BeLieVeR-HIFi trial): study design and rationale

C Davey  1 , Z Zoumot  1 , S Jordan  1 , D H Carr  1 , M I Polkey  1 , P L Shah  1 , N S Hopkinson  1
Affiliations
Randomized Controlled Trial

Bronchoscopic lung volume reduction with endobronchial valves for patients with heterogeneous emphysema and intact interlobar fissures (the BeLieVeR-HIFi trial): study design and rationale

C Davey et al. Thorax. 2015 Mar.

Abstract

Although lung volume reduction surgery improves survival in selected patients with emphysema, there has been ongoing interest in developing and evaluating bronchoscopic approaches to try to reduce lung volumes with less morbidity and mortality. The placement of endobronchial valves is one such technique, and although some patients have had a significant improvement, responses have been inconsistent because collateral ventilation prevents lobar atelectasis. We describe the protocol of a trial (ISRCTN04761234) aimed to show that a responder phenotype, patients with heterogeneous emphysema and intact interlobar fissures on CT scanning, can be identified prospectively, leading to a consistent benefit in clinical practice.

Keywords: Emphysema; Lung Volume Reduction Surgery.

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Figures

Figure 1
Figure 1
Flow diagram for the BeLieVeR-HIFi study.
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References

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