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Review
. 2014 Jan-Feb;37(1):3-9.
doi: 10.4103/2319-4170.125655.

The versatile functions of ATM kinase

Rebecca J Boohaker, Bo Xu  1
Affiliations
Review

The versatile functions of ATM kinase

Rebecca J Boohaker et al. Biomed J. 2014 Jan-Feb.

Abstract

Ataxia-telangiectasia mutated (ATM) kinase, the mutation of which causes the autosomal recessive disease ataxia-telangiectasia, plays an essential role in the maintenance of genome stability. Extensive studies have revealed that activated ATM signals to a massive list of proteins to facilitate cell cycle checkpoints, DNA repair, and many other aspects of physiological responses in the event of DNA double-strand breaks. ATM also plays functional roles beyond the well-characterized DNA damage response (DDR). In this review article, we discuss the recent findings on the molecular mechanisms of ATM in DDR, the mitotic spindle checkpoint, as well as hyperactive ATM signaling in cancer invasion and metastasis.

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Figures

Figure 1
Figure 1
ATM-mediated phosphorylation of downstream targets is required for activation of the DNA damage induced cell cycle checkpoints.
Figure 2
Figure 2
The schematic model of ATM activation in mitosis and its role in the spindle checkpoint.
Figure 3
Figure 3
Potential roles of ATM hyperactivation in tumor progression and metastasis.
See this image and copyright information in PMC

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