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. 2014 Jan;31(1):4-8.
doi: 10.4103/0970-2113.125886.

Impact of ventilator associated pneumonia on outcome in patients with chronic obstructive pulmonary disease exacerbation

Vijay Hadda  1 , Gopi Chand Khilnani  1 , Gajendra Dubey  2 , Rajkanna Nallan  2 , Guresh Kumar  3 , Randeep Guleria  1
Affiliations

Impact of ventilator associated pneumonia on outcome in patients with chronic obstructive pulmonary disease exacerbation

Vijay Hadda et al. Lung India. 2014 Jan.

Abstract

Background and objective: There are sparse data regarding the impact of ventilator-associated pneumonia (VAP) on outcome among patients with chronic obstructive pulmonary disease (COPD) exacerbation.

Materials and methods: This retrospective study included patients with COPD exacerbation requiring endotracheal intubation for more than 48 h admitted in a single respiratory unit from January 2008 to December 2009. Records of these patients were checked for the occurrence of VAP.

Results: One hundred and fifty-three patients required endotracheal intubation for COPD exacerbation during this period. The mean age of this cohort was 61.46 ± 11.3 years. The median duration of COPD was 6 years (range: 1-40). A total of 35 (22.8%) patients developed VAP (early: 9 and late: 26). The risk of mortality was comparable between two groups, that is, patients with and without VAP [odd's ratio (OR)-1.125; 95% confidence interval (CI), 0.622-2.035]. The duration of mechanical ventilation and hospital stay (median ± standard error, 95% CI) was 32 ± 10 (95% CI, 13-51) versus 10 ± 2 (95% CI, 6-14) days; P ≤ 0.001 and 53 ± 26 (95% CI, 3-103) versus 18 ± 7 (95% CI, 5-31) days; P = 0.031, respectively was higher among patients with VAP.

Conclusions: Our study has shown that VAP leads to increased duration of mechanical ventilation and hospital stay; however, the mortality is not affected.

Keywords: Chronic obstructive pulmonary disease; endotracheal intubation; in-hospital mortality; ventilator-associated pneumonia.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Kaplan-Meier survival curves comparing duration of mechanical ventilation between two groups
Figure 2
Figure 2
Kaplan-Meier survival curves comparing duration of hospital stay between two groups
See this image and copyright information in PMC

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