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. 2014 Jan-Feb;31(1):gin/31.1.9.

[Goodpasture's disease: a case series]

[Article in Italian]
Mauro Dugo, Alessandra Pasi, Pier Luigi Gatti, Stefania Mastrosimone, Licia Laurino, Giuseppina Barberio, Fabrizio Farneti, Cesarina Facchini, Maria Cristina Maresca
  • PMID: 24671842

[Goodpasture's disease: a case series]

[Article in Italian]
Mauro Dugo et al. G Ital Nefrol. 2014 Jan-Feb.

Abstract

Goodpasture's disease (GD) is an uncommon and severe autoimmune disorder caused by circulating autoantibodies directed against the glomerular basement membrane cross-reacting with the alveolar basement membrane. GD is clinically characterized by rapidly progressive glomerulonephritis, often associated with pulmonary hemorrhage representing a nephrological emergency. We present the clinical features of 9 cases, diagnosed in 1997-2012, in our Renal Unit. Contrary to previous reports, we found a predominance of GD in females and we observed unusual clinical patterns, such as the association with renal vein thrombosis in a pregnant patient, thrombosis of the pulmonary arteries and a late isolated recurrence of alveolitis. In dialysis-dependent patients, renal transplantation can represent an available treatment option.

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