Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1989 Jan;9(1):303-11.
doi: 10.1128/mcb.9.1.303-311.1989.

Anatomy of a new B-cell-specific enhancer

W Koch  1 , C Benoist, D Mathis
Affiliations
Comparative Study

Anatomy of a new B-cell-specific enhancer

W Koch et al. Mol Cell Biol. 1989 Jan.

Abstract

The major histocompatibility complex class II molecules, like the immunoglobulins, are prominent B-lymphocyte markers. Herein, we describe a B-cell-specific enhancer associated with the murine class II gene, Ek alpha. This enhancer has a complex anatomy that suggests interactions between remotely spaced elements. Of particular interest is the finding that two CCAAT boxes spaced one kilobase apart are important for enhancer activity. Somewhat surprisingly, the E alpha and immunoglobulin enhancers seem to show little resemblance.

PubMed Disclaimer

References

    1. Cell. 1988 May 6;53(3):357-70 - PubMed
    1. Science. 1988 Apr 8;240(4849):127-8 - PubMed
    1. J Exp Med. 1988 Jun 1;167(6):1781-90 - PubMed
    1. Mol Cell Biol. 1988 Oct;8(10):3975-87 - PubMed
    1. Genes Dev. 1988 Jul;2(7):786-800 - PubMed

Publication types