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. 1989 Apr 13;338(6216):557-62.
doi: 10.1038/338557a0.

Identification of angiogenic activity and the cloning and expression of platelet-derived endothelial cell growth factor

F Ishikawa  1 , K Miyazono, U Hellman, H Drexler, C Wernstedt, K Hagiwara, K Usuki, F Takaku, W Risau, C H Heldin
Affiliations

Identification of angiogenic activity and the cloning and expression of platelet-derived endothelial cell growth factor

F Ishikawa et al. Nature. .

Abstract

Cloning and sequencing of the complementary DNA for platelet-derived endothelial cell growth factor indicates that it is a novel factor distinct from previously characterized proteins. The factor, a protein with a relative molecular mass of about 45,000, stimulates endothelial cell growth and chemotaxis in vitro and angiogenesis in vivo.

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