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. 2014:2014:641039.
doi: 10.1155/2014/641039. Epub 2014 Feb 4.

Serum soluble triggering receptor expressed on myeloid cells-1 and procalcitonin can reflect sepsis severity and predict prognosis: a prospective cohort study

Zhenyu Li  1 , Hongxia Wang  1 , Jian Liu  1 , Bing Chen  1 , Guangping Li  2
Affiliations

Serum soluble triggering receptor expressed on myeloid cells-1 and procalcitonin can reflect sepsis severity and predict prognosis: a prospective cohort study

Zhenyu Li et al. Mediators Inflamm. 2014.

Abstract

Objective: To investigate the prognostic significance of serum soluble triggering receptor expressed on myeloid cells-1 (sTREM-1), procalcitonin (PCT), N-terminal probrain natriuretic peptide (NT-pro-BNP), C-reactive protein (CRP), cytokines, and clinical severity scores in patients with sepsis.

Methods: A total of 102 patients with sepsis were divided into survival group (n = 60) and nonsurvival group (n = 42) based on 28-day mortality. Serum levels of biomarkers and cytokines were measured on days 1, 3, and 5 after admission to an ICU, meanwhile the acute physiology and chronic health evaluation II (APACHE II) and sequential organ failure assessment (SOFA) scores were calculated.

Results: Serum sTREM-1, PCT, and IL-6 levels of patients in the nonsurvival group were significantly higher than those in the survival group on day 1 (P < 0.01). The area under a ROC curve for the prediction of 28 day mortality was 0.792 for PCT, 0.856 for sTREM-1, 0.953 for SOFA score, and 0.923 for APACHE II score. Multivariate logistic analysis showed that serum baseline sTREM-1 PCT levels and SOFA score were the independent predictors of 28-day mortality. Serum PCT, sTREM-1, and IL-6 levels showed a decrease trend over time in the survival group (P < 0.05). Serum NT-pro-BNP levels showed the predictive utility from days 3 and 5 (P < 0.05).

Conclusion: In summary, elevated serum sTREM-1 and PCT levels provide superior prognostic accuracy to other biomarkers. Combination of serum sTREM-1 and PCT levels and SOFA score can offer the best powerful prognostic utility for sepsis mortality.

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Figures

Figure 1
Figure 1
ROC curves for PCT, sTREM-1, SOFA, and APACHEII scores for predicting 28-day mortality on day 1. The area under a ROC curve for the prediction of 28-day mortality was 0.792 for PCT, 0.856 for sTREM-1, 0.953 for SOFA score, and 0.923 for APACHEII score. PCT and sTREM-1 showed the equal prognostic values which were inferior to SOFA and APACHEII scores (P < 0.05).
Figure 2
Figure 2
Dynamic changes of biomarkers and cytokines levels in survival group and nonsurvival group. Non-normally distribution data were made a logarithmic conversion into normally distribution data and expressed as means ± standard deviations (SD). a P < 0.01 for comparisons between two groups on the same day (Student's t-test).
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References

    1. Angus DC, Linde-Zwirble WT, Lidicker J, Clermont G, Carcillo J, Pinsky MR. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Critical Care Medicine. 2001;29(7):1303–1310. - PubMed
    1. Bouchon A, Dietrich J, Colonna M. Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes. Journal of Immunology. 2000;164(10):4991–4995. - PubMed
    1. Gibot S, Cravoisy A, Levy B, Bene M-C, Faure G, Bollaert P-E. Soluble triggering receptor expressed on myeloid cells and the diagnosis of pneumonia. The New England Journal of Medicine. 2004;350(5):451–458. - PubMed
    1. Assicot M, Gendrel D, Carsin H, Raymond J, Guilbaud J, Bohuon C. High serum procalcitonin concentrations in patients with sepsis and infection. The Lancet. 1993;341(8844):515–518. - PMC - PubMed
    1. Clerico A, Recchia FA, Passino C, Emdin M. Cardiac endocrine function is an essential component of the homeostatic regulation network: physiological and clinical implications. American Journal of Physiology—Heart and Circulatory Physiology. 2006;290(1):H17–H29. - PubMed

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