Expression of Prox1, D2-40, and WT1 in spindle cell hemangioma

Abstract

Background: Spindle cell hemangioma is a benign vascular proliferation that usually occurs on acral sites. A recent report showed focal positive staining of Prox1 in spindle cell hemangioma.

Methods: We performed an immunohistochemical study of spindle cell hemangioma with antibodies to CD31, D2-40, Prox1, smooth muscle actin (SMA) and Wilms tumor-1 (WT-1).

Results: The endothelial cells in spindle cell hemangioma were positive for CD31 and Prox1, focally positive for D2-40 and negative for WT-1, whereas the myoid spindle cells around the endothelial cells were weakly positive for WT-1.

Conclusion: Our results suggest that spindle cell hemangioma is a lymphatic malformation.

Keywords: D2-40; Prox1; Wilms tumor 1 (WT1); lymphatic; spindle cell hemangioma.