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. 2014 Apr 18;16(8):2146-9.
doi: 10.1021/ol500611d. Epub 2014 Mar 27.

Palladium-catalyzed oxidative annulation of acrylic acid and amide with alkynes: a practical route to synthesize α-pyrones and pyridones

Yue Yu  1 , Liangbin Huang, Wanqing Wu, Huanfeng Jiang
Affiliations

Palladium-catalyzed oxidative annulation of acrylic acid and amide with alkynes: a practical route to synthesize α-pyrones and pyridones

Yue Yu et al. Org Lett. .

Abstract

A range of internal alkynes smoothly underwent palladium-catalyzed oxidative annulations with acrylic acid and amide to afford α-pyrones and pyridones in good to excellent yields with high regioselectivity. The usage of O2 (1 atm) as a stoichiometric oxidant with H2O as the only byproduct under mild conditions makes this process more attractive and practical.

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