Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Multicenter Study
. 2014 Jul;166(2):250-3.
doi: 10.1111/bjh.12850. Epub 2014 Mar 27.

DNA copy number alterations mark disease progression in paediatric chronic myeloid leukaemia

Naomi E van der Sligte  1 , Manuela Krumbholz, Agata Pastorczak, Blanca Scheijen, Josephine T Tauer, Christina Nowasz, Edwin Sonneveld, Geertruida H de Bock, Tiny G J Meeuwsen-de Boer, Simon van Reijmersdal, Roland P Kuiper, Jutta Bradtke, Markus Metzler, Meinolf Suttorp, Evelina S J M de Bont, Frank N van Leeuwen
Affiliations
Multicenter Study

DNA copy number alterations mark disease progression in paediatric chronic myeloid leukaemia

Naomi E van der Sligte et al. Br J Haematol. 2014 Jul.

Erratum in

  • Br J Haematol. 2014 Nov;167(4):584

Abstract

Early recognition of children with chronic phase chronic myeloid leukaemia (CML-CP) at risk for developing a lymphoid blast crisis (LyBC) is desirable, because therapy options in CML-LyBC are limited. We used Multiplex Ligation-dependent Probe Amplification to determine whether B-cell lymphoid leukaemia-specific copy number alterations (CNAs) (e.g. IKZF1, PAX5, CDKN2A deletions) could be detected in CML-CP and may be used to predict disease progression to LyBC. CNAs were detected in all patients with CML-LyBC, but in none of the 77 patients with CML-CP. Based on this study we conclude that CNAs remain a hallmark of disease progression.

Keywords: IKZF1; copy number alterations; lymphoid blast crisis; paediatric CML.

PubMed Disclaimer

Publication types

Associated data

LinkOut - more resources