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. 2016 Apr;13(2):204-8.
doi: 10.1111/iwj.12260. Epub 2014 Mar 28.

Measurement of vancomycin hydrochloride concentration in the exudate from wounds receiving negative pressure wound therapy: a pilot study

Yukiko Ida  1 , Hajime Matsumura  1 , Masami Onishi  2 , Sayaka Ono  1 , Ryutaro Imai  1 , Katsueki Watanabe  1
Affiliations

Measurement of vancomycin hydrochloride concentration in the exudate from wounds receiving negative pressure wound therapy: a pilot study

Yukiko Ida et al. Int Wound J. 2016 Apr.

Abstract

It has been reported that negative pressure wound therapy (NPWT) is effective in the treatment of contaminated wounds. We hypothesised that systemically administered antibiotics migrate to wound site effectively by NPWT, which provides the antibacterial effect. We measured and compared the concentrations of vancomycin in the exudate and blood serum. Eight patients with skin ulcers or skin defect wounds who were treated with NPWT and were administered an intravenous drip of vancomycin were enrolled in this study. The wound surfaces were muscle, muscle fascia or adipose tissue. We administered vancomycin intravenously to NPWT patients (1-3 g/day). The exudate was obtained using 500 ml V.A.C. ATS canisters without gel. Three days later, the concentrations of vancomycin were measured. The mean concentration of vancomycin in the exudate from NPWT was 67% of the serum vancomycin concentration. We found that concentrations of vancomycin in NPWT exudates are higher than the previously reported concentrations in soft tissue without NPWT. The proactive use of NPWT might be considered in cases of suspected wound contamination when a systemic antibiotic is administered.

Keywords: Exudate; Infection; Negative pressure wound therapy; Vancomycin.

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Figures

Figure 1
Figure 1
Vancomycin concentrations in wound exudates are higher than the previously reported migration rate of vancomycin into the interstitial fluid. formula image: wound surface is muscle or muscle fascia. formula image, wound surface is adipose tissue. formula image, previously reported vancomycin migration rate into the interstitial fluid.
See this image and copyright information in PMC

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