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Review
. 2014 May;40(3):492-6.
doi: 10.1093/schbul/sbu042. Epub 2014 Mar 27.

Unlocking the treasure trove: from genes to schizophrenia biology

Shane E McCarthy  1 , W Richard McCombie, Aiden Corvin
Affiliations
Review

Unlocking the treasure trove: from genes to schizophrenia biology

Shane E McCarthy et al. Schizophr Bull. 2014 May.

Abstract

Significant progress is being made in defining the genetic etiology of schizophrenia. As the list of implicated genes grows, parallel developments in gene editing technology provide new methods to investigate gene function in model systems. The confluence of these two research fields--gene discovery and functional biology--may offer novel insights into schizophrenia etiology. We review recent advances in these fields, consider the likely obstacles to progress, and consider strategies as to how these can be overcome.

Keywords: CRISPR; genomics; model; schizophrenia; sequencing; systems.

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References

    1. Corvin A. Schizophrenia at a genetics crossroads: where to now? Schizophr Bull. 2013;39:490–495 - PMC - PubMed
    1. Ripke S, Sanders AR, Kendler KS, et al. Genome-wide association study identifies five new schizophrenia loci. Nat Genet. 2011;43:969–976 - PMC - PubMed
    1. Ripke S, O’Dushlaine C, Chambert K, et al. ; Multicenter Genetic Studies of Schizophrenia Consortium; Psychosis Endophenotypes International Consortium; Wellcome Trust Case Control Consortium 2 Genome-wide association analysis identifies 13 new risk loci for schizophrenia. Nat Genet. 2013;45:1150–1159 - PMC - PubMed
    1. Genetic Microsurgery for the Masses. Science. 2013; 342:1434–1435 - PubMed
    1. Cong L, Ran FA, Cox D, et al. Multiplex genome engineering using CRISPR/Cas systems. Science. 2013;339:819–823 - PMC - PubMed