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Comment
. 2014 Apr;46(4):321-3.
doi: 10.1038/ng.2930.

Ancient human oral plaque preserves a wealth of biological data

Jessica L Metcalf  1 , Luke K Ursell  1 , Rob Knight  1
Affiliations
Comment

Ancient human oral plaque preserves a wealth of biological data

Jessica L Metcalf et al. Nat Genet. 2014 Apr.

Abstract

A new study explores the ancient oral microbiome from the well-preserved dental calculus samples of four human individuals who lived during medieval times, using a suite of genomic, proteomic and microscopic approaches. The authors investigate the evolution of dental pathogens by reconstructing the genome of the periodontal pathogen Tannerella forsythia and also identify antibiotic resistance genes, bacterial virulence factors and host immune defense proteins.

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  • Pathogens and host immunity in the ancient human oral cavity.
    Warinner C, Rodrigues JF, Vyas R, Trachsel C, Shved N, Grossmann J, Radini A, Hancock Y, Tito RY, Fiddyment S, Speller C, Hendy J, Charlton S, Luder HU, Salazar-García DC, Eppler E, Seiler R, Hansen LH, Castruita JA, Barkow-Oesterreicher S, Teoh KY, Kelstrup CD, Olsen JV, Nanni P, Kawai T, Willerslev E, von Mering C, Lewis CM Jr, Collins MJ, Gilbert MT, Rühli F, Cappellini E. Warinner C, et al. Nat Genet. 2014 Apr;46(4):336-44. doi: 10.1038/ng.2906. Epub 2014 Feb 23. Nat Genet. 2014. PMID: 24562188 Free PMC article.

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