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. 1988 Aug:(83):234-9.

Clinical studies with granulocyte colony stimulating factor (G-CSF) in patients receiving cytotoxic chemotherapy

G Morstyn  1 , L Campbell, U Dührsen, L M Souza, N K Alton, J L Villeval, N A Nicola, A W Boyd, G Kannourakis, J Cebon, et al.
Affiliations
  • PMID: 2467651

Clinical studies with granulocyte colony stimulating factor (G-CSF) in patients receiving cytotoxic chemotherapy

G Morstyn et al. Behring Inst Mitt. 1988 Aug.

Abstract

Bacterially synthesised human granulocyte colony-stimulating factor (G-CSF) was administered to patients with advanced cancer. The immediate effect of G-CSF was a fall in the level of circulating neutrophils followed by a rise after 4 hours that was sustained during G-CSF administration. The rise in neutrophil level was less in patients who had been treated previously with chemotherapy and/or radiotherapy. G-CSF was also administered to patients following melphalan and this resulted in a reduction in the duration of the neutropenia that invariably follows melphalan. G-CSF was well tolerated and did not have to be stopped in any patient.

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