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Editorial
. 2014 Mar 28;114(7):1074-6.
doi: 10.1161/CIRCRESAHA.114.303684.

Modifying vascular calcification in diabetes mellitus: contribution of O-GlcNAcylation

Maximillian A Rogers  1 , Elena Aikawa
Affiliations
Editorial

Modifying vascular calcification in diabetes mellitus: contribution of O-GlcNAcylation

Maximillian A Rogers et al. Circ Res. .
No abstract available

Keywords: Editorials; diabetes mellitus; vascular calcification.

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Figures

Figure 1
Figure 1. Working hypothesis generated from the findings of the Heath et al. study
Diabetes associated hyperglycemia may lead to increased O-GlcNAcylation of AKT at the T430/T479 amino acids, causing increased AKT binding to the mTOR complex 2, and subsequent phosphorylation of AKT at S473, which may lead to increased Runx2 activity and the induction of vascular calcification.
Figure 2
Figure 2. Vascular calcification in diabetic mice
Aortic valve calcification imaging using a calcium sensitive near-infrared fluorescence (NIRF) probe (red) in apoE−/− diabetic (STZ+) mice and controls (STZ−). Aorta (Ao), aortic valve (AV), fibrous trigone (FT).
See this image and copyright information in PMC

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