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. 2014 Jun 4;26(21):3433-40.
doi: 10.1002/adma.201305256. Epub 2014 Feb 20.

Drug delivery with PEGylated MoS2 nano-sheets for combined photothermal and chemotherapy of cancer

Teng Liu  1 , Chao Wang, Xing Gu, Hua Gong, Liang Cheng, Xiaoze Shi, Liangzhu Feng, Baoquan Sun, Zhuang Liu
Affiliations

Drug delivery with PEGylated MoS2 nano-sheets for combined photothermal and chemotherapy of cancer

Teng Liu et al. Adv Mater. .

Abstract

MoS2 nanosheets functionalized with poly-ethylene glycol are for the first time used as a multifunctional drug delivery system with high drug loading capacities. Using doxorubicin as the model drug and taking advantages of the strong near-infrared absorbance of MoS2, combined photothermal and chemotherapy of cancer is realized in animal experiments, achieving excellent synergistic anti-tumor effect upon systemic administration.

Keywords: 2D nanostructure; MoS2 nanosheet; combination therapy; drug delivery; photothermal therapy.

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