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. 2014 Mar;4(1):1-25.
doi: 10.1556/EuJMI.4.2014.1.1. Epub 2014 Mar 14.

Molecular diagnosis of sepsis: New aspects and recent developments

O Liesenfeld, L Lehman, K-P Hunfeld, G Kost

Molecular diagnosis of sepsis: New aspects and recent developments

O Liesenfeld et al. Eur J Microbiol Immunol (Bp). 2014 Mar.

Abstract

By shortening the time to pathogen identification and allowing for detection of organisms missed by blood culture, new molecular methods may provide clinical benefits for the management of patients with sepsis. While a number of reviews on the diagnosis of sepsis have recently been published we here present up-to-date new developments including multiplex PCR, mass spectrometry and array techniques. We focus on those techniques that are commercially available and for which clinical studies have been performed and published.

Keywords: PCR; SeptiFast; biomarker; blood culture; mass spectrometry; microarray; molecular diagnostics; sepsis.

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Figures

Fig. 1.
Fig. 1.
Diagnostic techniques for the diagnosis of sepsis (modified after [21])
Fig. 2.
Fig. 2.
Time to result of selected blood culture-dependent and blood culture-independent technologies for the diagnosis of sepsis; the vertical line indicates the duration of blood culture (fixed at 8 h or longer for this figure)
See this image and copyright information in PMC

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