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. 2014 Mar 29:14:38.
doi: 10.1186/1471-2415-14-38.

Adjusted color probability codes for peripapillary retinal nerve fiber layer thickness in healthy Koreans

Samin Hong, Sang-Myung Kim, Kyoungsoo Park, Jun Mo Lee, Chan Yun Kim, Gong Je Seong  1
Affiliations

Adjusted color probability codes for peripapillary retinal nerve fiber layer thickness in healthy Koreans

Samin Hong et al. BMC Ophthalmol. .

Abstract

Background: Though a newly developed spectral domain optical coherence tomography (OCT) is at the center of interests for many ophthalmologic researchers and clinicians, its own characteristics are not fully evaluated yet. The main purpose of this study was to establish the adjusted color probability codes for peripapillary retinal nerve fiber layer (RNFL) thickness in healthy Koreans and to compare them with original color codes provided by spectral domain OCT.

Methods: Two hundred ninety-five healthy Korean eyes were enrolled and their peripapillary RNFL thickness was measured by Cirrus OCT. For each decade of age, the normal thickness reference was determined on the basis of z-scores and the adjusted color probability codes were established. Then the agreements between adjusted and original color codes were calculated using weighted Kappa (Kw) coefficient.

Results: On the basis of Kw coefficient, the overall agreement between the adjusted and original probability color codes was not excellent (Kw range of 0.500 to 0.806). If the adjusted probability codes were assumed as a standard of comparison, the original color codes showed the false-negative in 11% of eyes and the false-positive in 0.3% of eyes for average RNFL thickness.

Conclusions: Adjusted color probability codes judged by the Korean normative data showed a discrepancy with original codes. It implies that normal reference and adjusted probability codes for each ethnicity might be needed to determine whether a certain RNFL thickness is within normal range or not.

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Figures

Figure 1
Figure 1
Adjusted probability codes obtained on the basis of each z-score for a one-tailed normal probability of 5% (z = 1.645) and 1% (z = 2.327). μ = mean; σ = standard deviation.
Figure 2
Figure 2
Peripapillary retinal nerve fiber layer thickness according to age in healthy Koreans. Asterisks indicate statistically significant differences (p < 0.050).
Figure 3
Figure 3
Normal distributions of retinal nerve fiber layer thickness in each decade of age for the Korean population.
Figure 4
Figure 4
Theoretical causes of the discrepancy between adjusted and original probability codes: the means (A) or standard deviations (B) might be different.
See this image and copyright information in PMC

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