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. 1989 May;63(5):2352-6.
doi: 10.1128/JVI.63.5.2352-2356.1989.

Alterations in the structure of new and old forms of simian virus 40 large T antigen (T) defined by age-dependent epitope changes: new T is the same as ATPase-active T

L C Tack  1 , J H Wright, E G Gurney
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Alterations in the structure of new and old forms of simian virus 40 large T antigen (T) defined by age-dependent epitope changes: new T is the same as ATPase-active T

L C Tack et al. J Virol. 1989 May.

Abstract

The reactivity of simian virus 40 large T antigen labeled under pulse-chase conditions towards 22 antibodies was measured. Changes in epitope reactivity occurred in several domains of T as it matured, defining major structural alterations that distinguished mature from new molecules. New T reacted best with the same antibodies that bind and inhibit ATPase-active T. These antibodies thus can distinguish new T as a distinct structural and functional form.

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