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. 1989 Apr;35(4):428-32.

Transfer RNA is cleaved by activated bleomycin

R S Magliozzo  1 , J Peisach, M R Ciriolo
Affiliations
  • PMID: 2468077

Transfer RNA is cleaved by activated bleomycin

R S Magliozzo et al. Mol Pharmacol. 1989 Apr.

Abstract

Activated bleomycin is shown for the first time to cleave tRNA in a specific and dose-dependent manner. Adenine and uracil are released in the reaction. Bleomycin and Fe(III)-bleomycin bind to yeast tRNAPhe) in analogy with the known behavior of the drug with B-DNA.

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