. 2014 Sep;192(3):947-55.

doi: 10.1016/j.juro.2014.03.093. Epub 2014 Mar 26.

Alterations in resting state oscillations and connectivity in sensory and motor networks in women with interstitial cystitis/painful bladder syndrome

Lisa A Kilpatrick¹, Jason J Kutch¹, Kirsten Tillisch¹, Bruce D Naliboff¹, Jennifer S Labus¹, Zhiguo Jiang¹, Melissa A Farmer¹, A Vania Apkarian¹, Sean Mackey¹, Katherine T Martucci¹, Daniel J Clauw¹, Richard E Harris¹, Georg Deutsch¹, Timothy J Ness¹, Claire C Yang¹, Kenneth Maravilla¹, Chris Mullins¹, Emeran A Mayer²

Affiliations

¹ Gail and Gerald Oppenheimer Family Center for Neurobiology of Stress, David Geffen School of Medicine, University of California-Los Angeles (LAK, KT, BDN, JSL, ZJ, EAM), Los Angeles, California; Division of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles (JJK), California; Division of Pain Medicine, Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University Medical Center (SM, KTM), Stanford, California; Human Performance and Engineering Laboratory, Kessler Foundation Research Center, West Orange and Department of Biomedical Engineering, New Jersey Institute of Technology, Newark, New Jersey (ZJ); Department of Physiology, Feinberg School of Medicine, Northwestern University (MAF, AVA), Chicago, Illinois; Department of Anesthesiology, Chronic Pain and Fatigue Research Center, University of Michigan (DJC, REH), Ann Arbor, Michigan; Departments of Radiology and Anesthesiology, University of Alabama, Birmingham Medical Center (GD, TJN), Birmingham, Alabama; Department of Urology (CCY), University of Washington, Seattle, Washington; Department of Radiology (KTM), University of Washington, Seattle, Washington; National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health (CM), Bethesda, Maryland.
² Gail and Gerald Oppenheimer Family Center for Neurobiology of Stress, David Geffen School of Medicine, University of California-Los Angeles (LAK, KT, BDN, JSL, ZJ, EAM), Los Angeles, California; Division of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles (JJK), California; Division of Pain Medicine, Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University Medical Center (SM, KTM), Stanford, California; Human Performance and Engineering Laboratory, Kessler Foundation Research Center, West Orange and Department of Biomedical Engineering, New Jersey Institute of Technology, Newark, New Jersey (ZJ); Department of Physiology, Feinberg School of Medicine, Northwestern University (MAF, AVA), Chicago, Illinois; Department of Anesthesiology, Chronic Pain and Fatigue Research Center, University of Michigan (DJC, REH), Ann Arbor, Michigan; Departments of Radiology and Anesthesiology, University of Alabama, Birmingham Medical Center (GD, TJN), Birmingham, Alabama; Department of Urology (CCY), University of Washington, Seattle, Washington; Department of Radiology (KTM), University of Washington, Seattle, Washington; National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health (CM), Bethesda, Maryland. Electronic address: emayer@ucla.edu.

PMID: 24681331
PMCID: PMC4432915
DOI: 10.1016/j.juro.2014.03.093

Alterations in resting state oscillations and connectivity in sensory and motor networks in women with interstitial cystitis/painful bladder syndrome

Lisa A Kilpatrick et al. J Urol. 2014 Sep.

. 2014 Sep;192(3):947-55.

doi: 10.1016/j.juro.2014.03.093. Epub 2014 Mar 26.

Authors

Affiliations

¹ Gail and Gerald Oppenheimer Family Center for Neurobiology of Stress, David Geffen School of Medicine, University of California-Los Angeles (LAK, KT, BDN, JSL, ZJ, EAM), Los Angeles, California; Division of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles (JJK), California; Division of Pain Medicine, Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University Medical Center (SM, KTM), Stanford, California; Human Performance and Engineering Laboratory, Kessler Foundation Research Center, West Orange and Department of Biomedical Engineering, New Jersey Institute of Technology, Newark, New Jersey (ZJ); Department of Physiology, Feinberg School of Medicine, Northwestern University (MAF, AVA), Chicago, Illinois; Department of Anesthesiology, Chronic Pain and Fatigue Research Center, University of Michigan (DJC, REH), Ann Arbor, Michigan; Departments of Radiology and Anesthesiology, University of Alabama, Birmingham Medical Center (GD, TJN), Birmingham, Alabama; Department of Urology (CCY), University of Washington, Seattle, Washington; Department of Radiology (KTM), University of Washington, Seattle, Washington; National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health (CM), Bethesda, Maryland.
² Gail and Gerald Oppenheimer Family Center for Neurobiology of Stress, David Geffen School of Medicine, University of California-Los Angeles (LAK, KT, BDN, JSL, ZJ, EAM), Los Angeles, California; Division of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles (JJK), California; Division of Pain Medicine, Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University Medical Center (SM, KTM), Stanford, California; Human Performance and Engineering Laboratory, Kessler Foundation Research Center, West Orange and Department of Biomedical Engineering, New Jersey Institute of Technology, Newark, New Jersey (ZJ); Department of Physiology, Feinberg School of Medicine, Northwestern University (MAF, AVA), Chicago, Illinois; Department of Anesthesiology, Chronic Pain and Fatigue Research Center, University of Michigan (DJC, REH), Ann Arbor, Michigan; Departments of Radiology and Anesthesiology, University of Alabama, Birmingham Medical Center (GD, TJN), Birmingham, Alabama; Department of Urology (CCY), University of Washington, Seattle, Washington; Department of Radiology (KTM), University of Washington, Seattle, Washington; National Institute of Diabetes, Digestive and Kidney Diseases, National Institutes of Health (CM), Bethesda, Maryland. Electronic address: emayer@ucla.edu.

PMID: 24681331
PMCID: PMC4432915
DOI: 10.1016/j.juro.2014.03.093

Abstract

Purpose: The pathophysiology of interstitial cystitis/painful bladder syndrome remains incompletely understood but is thought to involve central disturbance in the processing of pain and viscerosensory signals. We identified differences in brain activity and connectivity between female patients with interstitial cystitis/painful bladder syndrome and healthy controls to advance clinical phenotyping and treatment efforts for interstitial cystitis/painful bladder syndrome.

Materials and methods: We examined oscillation dynamics of intrinsic brain activity in a large sample of well phenotyped female patients with interstitial cystitis/painful bladder syndrome and female healthy controls. Data were collected during 10-minute resting functional magnetic resonance imaging as part of the Multidisciplinary Approach to the Study of Chronic Pelvic Pain Research Network project. The blood oxygen level dependent signal was transformed to the frequency domain. Relative power was calculated for multiple frequency bands.

Results: Results demonstrated altered frequency distributions in viscerosensory (post insula), somatosensory (postcentral gyrus) and motor regions (anterior paracentral lobule, and medial and ventral supplementary motor areas) in patients with interstitial cystitis/painful bladder syndrome. Also, the anterior paracentral lobule, and medial and ventral supplementary motor areas showed increased functional connectivity to the midbrain (red nucleus) and cerebellum. This increased functional connectivity was greatest in patients who reported pain during bladder filling.

Conclusions: Findings suggest that women with interstitial cystitis/painful bladder syndrome have a sensorimotor component to the pathological condition involving an alteration in intrinsic oscillations and connectivity in a cortico-cerebellar network previously associated with bladder function.

Keywords: brain mapping; cystitis; interstitial; magnetic resonance imaging; pain; urinary bladder.

PubMed Disclaimer

Figures

**Figure 1**
(A) PelMotor, SMA, and paracentral lobule (shown in red) demonstrated increased LF power and increased LF connectivity with a region in the right midbrain (red nucleus) and regions within the cerebellular vermis VI/VII and right lobule VI (shown in yellow) in patients compared to controls. (B) pINS (shown in blue) demonstrated decreased LF power and decreased LF connectivity with mINS (shown in green) in patients compared to controls.

**Figure 2**
(A) The estimated mean functional connectivity (controlling for age ) between PelMotor, SMA, paracentral lobule and red nucleus/cerebellar regions (RN/cere) is shown for healthy controls, IC/PBS with pain during bladder filling (IC/PBS yes) and IC/PBS without pain during bladder filling (IC/PBS no). (B) Functional connectivity values are plotted for each individual within each of the 5 scanning sites. *p<0.05 compared to controls **p<0.05 compared to controls and IC/PBS no

See this image and copyright information in PMC

Cited by

Multivariate morphological brain signatures predict patients with chronic abdominal pain from healthy control subjects.
Labus JS, Van Horn JD, Gupta A, Alaverdyan M, Torgerson C, Ashe-McNalley C, Irimia A, Hong JY, Naliboff B, Tillisch K, Mayer EA. Labus JS, et al. Pain. 2015 Aug;156(8):1545-1554. doi: 10.1097/j.pain.0000000000000196. Pain. 2015. PMID: 25906347 Free PMC article.
Relationship of Pain Catastrophizing With Urinary Biomarkers in Women With Bladder Pain Syndrome.
Soriano A, Allen A, Malykhina AP, Andy U, Harvie H, Arya L. Soriano A, et al. Female Pelvic Med Reconstr Surg. 2021 Dec 1;27(12):746-752. doi: 10.1097/SPV.0000000000001041. Female Pelvic Med Reconstr Surg. 2021. PMID: 33787562 Free PMC article.
Quantitative assessment of nonpelvic pressure pain sensitivity in urologic chronic pelvic pain syndrome: a MAPP Research Network study.
Harte SE, Schrepf A, Gallop R, Kruger GH, Lai HHH, Sutcliffe S, Halvorson M, Ichesco E, Naliboff BD, Afari N, Harris RE, Farrar JT, Tu F, Landis JR, Clauw DJ; MAPP Research Network. Harte SE, et al. Pain. 2019 Jun;160(6):1270-1280. doi: 10.1097/j.pain.0000000000001505. Pain. 2019. PMID: 31050659 Free PMC article.
Impact of early adverse life events and sex on functional brain networks in patients with urological chronic pelvic pain syndrome (UCPPS): A MAPP Research Network study.
Gupta A, Bhatt RR, Naliboff BD, Kutch JJ, Labus JS, Vora PP, Alaverdyan M, Schrepf A, Lutgendorf S, Mayer EA; MAPP Research Network. Gupta A, et al. PLoS One. 2019 Jun 20;14(6):e0217610. doi: 10.1371/journal.pone.0217610. eCollection 2019. PLoS One. 2019. PMID: 31220089 Free PMC article.
OPRM1 A118G polymorphism modulating motor pathway for pain adaptability in women with primary dysmenorrhea.
Hsu PS, Cheng CM, Chao HT, Lin MW, Li WC, Lee LC, Liu CH, Chen LF, Hsieh JC. Hsu PS, et al. Front Neurosci. 2023 Jun 12;17:1179851. doi: 10.3389/fnins.2023.1179851. eCollection 2023. Front Neurosci. 2023. PMID: 37378013 Free PMC article.

See all "Cited by" articles

References

1. Berry SH, Elliott MN, Suttorp M, et al. Prevalence of symptoms of bladder pain syndrome/interstitial cystitis among adult females in the United States. J Urol. 2011;186:540. - PMC - PubMed
1. Clemens JQ. Male and female pelvic pain disorders--is it all in their heads? J Urol. 2008;179:813. - PubMed
1. Mayer E, Bushnell M. Functional pain disorders: Time for a paradigm shift? In: Mayer E, Bushnell M, editors. Functional Pain Syndromes: Presentation and Pathophysiology. Seattle: IASP Press; 2009.
1. Farmer MA, Chanda ML, Parks EL, et al. Brain functional and anatomical changes in chronic prostatitis/chronic pelvic pain syndrome. J Urol. 2011;186:117. - PMC - PubMed
1. Kutch J, Yani M, Cossand L, et al. Altered neuromotor connectivity in men with urologic chronic pelvic pain syndrome: A Trans-MAPP neuroimaging study. Journal of Urology. submitted.

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions

Grants and funding

LinkOut - more resources

Full Text Sources
Other Literature Sources
- H1 Connect - Access expert opinions and insights on biomedical research.
- scite Smart Citations
Medical
- ClinicalTrials.gov
- MedlinePlus Health Information

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Alterations in resting state oscillations and connectivity in sensory and motor networks in women with interstitial cystitis/painful bladder syndrome

Affiliations

Alterations in resting state oscillations and connectivity in sensory and motor networks in women with interstitial cystitis/painful bladder syndrome

Authors

Affiliations

Abstract

Figures

Similar articles

Cited by

References

Publication types

MeSH terms

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Abstract

Figures

Similar articles

Cited by

References

Publication types

MeSH terms

Related information

Grants and funding

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical