Review
[Bone and Stem Cells. Isolation and immunomodulation of mesenchymal stem cells]
[Article in
Japanese]
Affiliations
- PMID: 24681504
Item in Clipboard
Review
[Bone and Stem Cells. Isolation and immunomodulation of mesenchymal stem cells]
[Article in
Japanese]
Clin Calcium.
2014 Apr.
Abstract
Mesenchymal stem cells (MSCs) are important clinical applications in treating immune disorders due to their multipotency, immunosuppressive properties by production of cytokines. However, the majority of studies rely on an in vitro cell expansion phase, and the properties of MSCs in vivo are still unknown, because there is no specific marker for MSCs. The purpose of this review is to provide an update on our knowledge of MSCs isolation and their immunosuppressive properties, focusing on bone marrow-derived MSCs.
Similar articles
-
Large-scale expansion of pre-isolated bone marrow mesenchymal stromal cells in serum-free conditions.J Tissue Eng Regen Med. 2016 Feb;10(2):108-19. doi: 10.1002/term.1713. Epub 2013 Mar 12. J Tissue Eng Regen Med. 2016. PMID: 23495227
-
Are mesenchymal stromal cells immune cells?Arthritis Res Ther. 2015 Mar 31;17(1):88. doi: 10.1186/s13075-015-0596-3. Arthritis Res Ther. 2015. PMID: 25880839 Free PMC article. Review.
-
Isolation, expansion and characterization of bone marrow-derived mesenchymal stromal cells in serum-free conditions.Cell Tissue Res. 2014 Apr;356(1):123-35. doi: 10.1007/s00441-013-1783-7. Epub 2014 Jan 22. Cell Tissue Res. 2014. PMID: 24448665
-
Mesenchymal stem cells as immunomodulator therapies for immune-mediated systemic dermatoses.Stem Cells Dev. 2012 Feb 10;21(3):352-62. doi: 10.1089/scd.2011.0404. Epub 2011 Oct 18. Stem Cells Dev. 2012. PMID: 21864110 Review.
-
Human mesenchymal stem cells (MSCs) for treatment towards immune- and inflammation-mediated diseases: review of current clinical trials.J Biomed Sci. 2016 Nov 4;23(1):76. doi: 10.1186/s12929-016-0289-5. J Biomed Sci. 2016. PMID: 27809910 Free PMC article. Review.