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. 2014 Apr;21(4):423-5.
doi: 10.1038/nsmb.2799. Epub 2014 Mar 30.

The retrovirus HERVH is a long noncoding RNA required for human embryonic stem cell identity

Xinyi Lu  1 , Friedrich Sachs  2 , LeeAnn Ramsay  3 , Pierre-Étienne Jacques  4 , Jonathan Göke  1 , Guillaume Bourque  5 , Huck-Hui Ng  6
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The retrovirus HERVH is a long noncoding RNA required for human embryonic stem cell identity

Xinyi Lu et al. Nat Struct Mol Biol. 2014 Apr.

Abstract

Human endogenous retrovirus subfamily H (HERVH) is a class of transposable elements expressed preferentially in human embryonic stem cells (hESCs). Here, we report that the long terminal repeats of HERVH function as enhancers and that HERVH is a nuclear long noncoding RNA required to maintain hESC identity. Furthermore, HERVH is associated with OCT4, coactivators and Mediator subunits. Together, these results uncover a new role of species-specific transposable elements in hESCs.

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References

    1. PLoS Genet. 2013 Apr;9(4):e1003470 - PubMed
    1. Genome Biol. 2012 Nov 26;13(11):R107 - PubMed
    1. PLoS Genet. 2013 May;9(5):e1003504 - PubMed
    1. Nat Rev Genet. 2008 May;9(5):397-405 - PubMed
    1. Nat Rev Genet. 2011 May;12(5):300 - PubMed

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