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Meta-Analysis
. 2014 Mar 28;9(3):e93471.
doi: 10.1371/journal.pone.0093471. eCollection 2014.

Intake of fruit juice and incidence of type 2 diabetes: a systematic review and meta-analysis

Bo Xi  1 , Shuangshuang Li  1 , Zhaolu Liu  1 , Huan Tian  1 , Xiuxiu Yin  1 , Pengcheng Huai  2 , Weihong Tang  3 , Donghao Zhou  4 , Lyn M Steffen  3
Affiliations
Meta-Analysis

Intake of fruit juice and incidence of type 2 diabetes: a systematic review and meta-analysis

Bo Xi et al. PLoS One. .

Abstract

Background: Several prospective studies have been conducted to examine the relationship between fruit juice intake and risk of incident type 2 diabetes, but results have been mixed. In the present study, we aimed to estimate the association between fruit juice intake and risk of type 2 diabetes.

Methods: PubMed and Embase databases were searched up to December 2013. All prospective cohort studies of fruit juice intake with risk of type 2 diabetes were included. The pooled relative risks (RRs) with 95% confidence intervals (CIs) for highest vs. lowest category of fruit juice intake were estimated using a random-effects model.

Results: A total of four studies (191,686 participants, including 12,375 with type 2 diabetes) investigated the association between sugar-sweetened fruit juice and risk of incident type 2 diabetes, and four studies (137,663 participants and 4,906 cases) investigated the association between 100% fruit juice and risk of incident type 2 diabetes. A higher intake of sugar-sweetened fruit juice was significantly associated with risk of type 2 diabetes (RR = 1.28, 95%CI = 1.04-1.59, p = 0.02), while intake of 100% fruit juice was not associated with risk of developing type 2 diabetes (RR = 1.03, 95% CI = 0.91-1.18, p = 0.62).

Conclusions: Our findings support dietary recommendations to limit sugar-sweetened beverages, such as fruit juice with added sugar, to prevent the development of type 2 diabetes.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Process of study selection.
Figure 2
Figure 2. Relative risk for incident type 2 diabetes for highest versus lowest intake of fruit juice (by type of juice).
Figure 3
Figure 3. Funnel plot of the association between intake of fruit juice and incident type 2 diabetes.
See this image and copyright information in PMC

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