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Review
. 2014 Mar;28(2):81-97.
doi: 10.7555/JBR.27.20120136. Epub 2013 Jun 6.

A clinical perspective on mucoadhesive buccal drug delivery systems

Ritu M Gilhotra  1 , Mohd Ikram  1 , Sunny Srivastava  1 , Neeraj Gilhotra  2
Affiliations
Review

A clinical perspective on mucoadhesive buccal drug delivery systems

Ritu M Gilhotra et al. J Biomed Res. 2014 Mar.

Abstract

Mucoadhesion can be defined as a state in which two components, of which one is of biological origin, are held together for extended periods of time by the help of interfacial forces. Among the various transmucosal routes, buccal mucosa has excellent accessibility and relatively immobile mucosa, hence suitable for administration of retentive dosage form. The objective of this paper is to review the works done so far in the field of mucoadhesive buccal drug delivery systems (MBDDS), with a clinical perspective. Starting with a brief introduction of the mucoadhesive drug delivery systems, oral mucosa, and the theories of mucoadhesion, this article then proceeds to cover the works done so far in the field of MBDDS, categorizing them on the basis of ailments they are meant to cure. Additionally, we focus on the various patents, recent advancements, and challenges as well as the future prospects for mucoadhesive buccal drug delivery systems.

Keywords: buccal mucosa; clinical perspective; mucoadhesion; patents; transmucosal route.

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Conflict of interest statement

The authors reported no conflict of interests.

Figures

Fig. 1
Fig. 1. Two main sites for drug delivery in the oral cavity.
Fig. 2
Fig. 2. A cross section of the oral mucosa.
See this image and copyright information in PMC

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