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. 2014 Aug;35(8):1958.e1-2.
doi: 10.1016/j.neurobiolaging.2014.03.004. Epub 2014 Mar 5.

Genetic variation of the retromer subunits VPS26A/B-VPS29 in Parkinson's disease

Barbara Shannon  1 , Alexandra Soto-Ortolaza  1 , Sruti Rayaprolu  1 , Heather D Cannon  1 , Catherine Labbé  1 , Bruno A Benitez  2 , Jiyoon Choi  2 , Timothy Lynch  3 , Magdalena Boczarska-Jedynak  4 , Grzegorz Opala  4 , Anna Krygowska-Wajs  5 , Maria Barcikowska  6 , Jay A Van Gerpen  7 , Ryan J Uitti  7 , Wolfdieter Springer  8 , Carlos Cruchaga  2 , Zbigniew K Wszolek  7 , Owen A Ross  9
Affiliations

Genetic variation of the retromer subunits VPS26A/B-VPS29 in Parkinson's disease

Barbara Shannon et al. Neurobiol Aging. 2014 Aug.

Abstract

We recently showed that mutation of the VPS35 gene can cause late-onset Parkinson's disease. In the present study we sequenced 702 affected subjects from the Mayo Clinic Parkinson's disease patient-control series for the VPS29 and VPS26A/B genes. We identified only 2 rare nonsynonymous variants in the VPS26A p.K93E and VPS29 p.N72H. The results show that mutations in the genes composing the retromer cargo recognition subunit are not a common cause of Parkinson's disease.

Keywords: Genetics; Parkinson's disease and/or Parkinsonism; Retromer; VPS35.

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Conflict of interest statement

Disclosure Statement

All authors declare no actual or potential conflicts of interest.

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