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. 1989 Mar;10(3):186-9.
doi: 10.1002/elps.1150100306.

A simple, sensitive method of analyzing bacterial ribosomal DNA polymorphism

N Picard-Pasquier  1 , M Ouagued, B Picard, P Goullet, R Krishnamoorthy
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A simple, sensitive method of analyzing bacterial ribosomal DNA polymorphism

N Picard-Pasquier et al. Electrophoresis. 1989 Mar.

Abstract

A rapid DNA extraction procedure and random primer labelling of Escherichia coli ribosomal RNA with cloned reverse transcriptase have been used to establish a simple and highly sensitive method for studying ribosomal DNA polymorphism in bacteria. Examples of inter- and intraspecies differentiation of bacteria are given and potential applications in bacterial epidemiology and taxonomy are discussed.

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