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. 1988 Dec;19(4):321-7.
doi: 10.1016/0165-2478(88)90162-9.

Human monocyte activation induced by an anti-CD14 monoclonal antibody

C Schütt  1 , B Ringel, M Nausch, V Bazil, V Horejsí, P Neels, H Walzel, L Jonas, E Siegl, H Friemel, et al.
Affiliations

Human monocyte activation induced by an anti-CD14 monoclonal antibody

C Schütt et al. Immunol Lett. 1988 Dec.

Abstract

An anti-CD14 mAb RoMo-1 rapidly induces in human monocytes a transient oxidative burst activity as detected by chemiluminescence assay. Pretreatment of these cells with the mAb markedly suppresses the monocyte chemiluminescence response to opsonized zymosan. In addition, the antibody induces a significant increase of IL-1 production and secretion by mononuclear cells, comparable to a similar effect of rIFN-gamma or LPS. Electron microscopy demonstrates internalization of the CD14 molecules after interaction with the mAb in a characteristic receptor-like manner.

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