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. 1989 Jan;35(1):95-8.
doi: 10.1038/ki.1989.13.

Plasma 5-hydroxyindoleacetic acid as an endogenous index of renal plasma flow

T Hannedouche  1 , D Laude, M Déchaux, J P Grünfeld, J L Elghozi
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Free article

Plasma 5-hydroxyindoleacetic acid as an endogenous index of renal plasma flow

T Hannedouche et al. Kidney Int. 1989 Jan.
Free article

Abstract

5-Hydroxyindoleacetic acid (5-HIAA), the major serotonin metabolite, was measured in human plasma and urine using liquid chromatography and electrochemical detection. The renal extraction of 5-HIAA was 78%, a value compatible with an almost complete extraction during a single passage of the blood through the kidney. In addition, plasma levels of 5-HIAA measured in patients with a wide range of renal function was inversely correlated (r = 0.85) with the clearance of para-aminohippuric acid (PAH). The results indicate that 5-HIAA determinations can be used as an alternative procedure to the PAH clearance method for the estimation of renal plasma flow in clinical practice.

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