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Review
. 2014 Apr;6(2):54-61.
doi: 10.1177/1756287213511508.

Antibiotic resistance in pediatric urology

Rachel S Edlin  1 , Hillary L Copp  2
Affiliations
Review

Antibiotic resistance in pediatric urology

Rachel S Edlin et al. Ther Adv Urol. 2014 Apr.

Abstract

Antibiotics are a mainstay in the treatment of bacterial infections, though their use is a primary risk factor for the development of antibiotic resistance. Antibiotic resistance is a growing problem in pediatric urology as demonstrated by increased uropathogen resistance. Lack of urine testing, nonselective use of prophylaxis, and poor empiric prescribing practices exacerbate this problem. This article reviews antibiotic utilization in pediatric urology with emphasis on modifiable practice patterns to potentially help mitigate the growing rates of antibiotic resistance. This includes urine testing to only treat when indicated and tailor broad-spectrum therapy as able; selective application of antibiotic prophylaxis to patients with high-grade vesicoureteral reflux and hydronephrosis with counseling regarding the importance of compliance; and using local antiobiograms, particularly pediatric-specific antiobiograms, with inpatient versus outpatient data.

Keywords: antibiogram; antibiotic prophylaxis; antibiotic resistance; patient compliance; pediatrics; treatment outcome; urinary tract infections.

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Conflict of interest statement

Conflict of interest statement: The authors declare no conflicts of interest in preparing this article.

References

    1. Allen U., Macdonald N., Fuite L., Chan F., Stephens D. (1999) Risk factors for resistance to ‘first-line’ antimicrobials among urinary tract isolates of Escherichia coli in children. CMAJ 160: 1436–1440 - PMC - PubMed
    1. Austin D., Kristinsson K., Anderson R. (1999) The relationship between the volume of antimicrobial consumption in human communities and the frequency of resistance. Proc Natl Acad Sci U S A 96: 1152–1156 - PMC - PubMed
    1. Bartoloni A., Bartalesi F., Mantella A., Dell’Amico E., Roselli M., Strohmeyer M., et al. (2004) High prevalence of acquired antimicrobial resistance unrelated to heavy antimicrobial consumption. J Infect Dis 189: 1291–1294 - PubMed
    1. Boggan J., Navar-Boggan A., Jhaveri R. (2012) Pediatric-specific antimicrobial susceptibility data and empiric antibiotic selection. Pediatrics 130: e615-e622 - PubMed
    1. Bollgren I. (1999) Antibacterial prophylaxis in children with urinary tract infection. Acta Paediatr Suppl 88: 48–52 - PubMed