The innovative medicines initiative: a public private partnership model to foster drug discovery
- PMID: 24688725
- PMCID: PMC3962198
- DOI: 10.5936/csbj.201303017
The innovative medicines initiative: a public private partnership model to foster drug discovery
Abstract
The Innovative Medicines Initiative (IMI) is a large-scale public-private partnership between the European Commission and the European Federation of Pharmaceutical Industries and Associations (EFPIA). IMI aims to boost the development of new medicines across Europe by implementing new collaborative endeavours between large pharmaceutical companies and other key actors in the health-care ecosystem, i.e., academic institutions, small and medium enterprises, patients, and regulatory authorities. Currently there are more than 40 IMI projects covering the whole value chain of pharmaceutical R&D, but with a strong focus on drug discovery, as an ideal arena where the PPP concept of pre-competitive collaboration can rapidly deliver results. This article review recent achievements of the IMI consortia of relevance to drug discovery, providing proof-of-concept evidence for the efficiency of this new model of collaboration.
Keywords: attrition rate; bottlenecks; drug efficacy; drug safety; knowledge management; pharmaceutical industry.
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References
-
- Munos B. (2009) Lessons from 60 years of pharmaceutical innovation. Nat. Rev. Drug Discov. 12:959–968 - PubMed
-
- Economist Intelligence Unit (2011) The future of healthcare in Europe. http://www.janssen-emea.com/sites/default/files/The-Future-Of-Healthcare...
-
- Kola I, Landis J. (2004) Can the pharmaceutical industry reduce attrition rates? Nat Rev Drug Discov. 3(8):711–715 - PubMed
-
- Paul SM, Mytelka DS, Dunwiddie CT, Persinger CC, Munos BH, et al. (2010) How to improve R&D productivity: the pharmaceutical industry's grand challenge. Nat Rev Drug Discov. 9(3):203–214 - PubMed
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