Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2013 Nov 1;2013(1):29-36.
doi: 10.5339/gcsp.2013.5. eCollection 2013.

Bioengineering and the cardiovascular system

Robert M Nerem  1
Affiliations
Review

Bioengineering and the cardiovascular system

Robert M Nerem. Glob Cardiol Sci Pract. .

Abstract

The development of the modern era of bioengineering and the advances in our understanding of the cardiovascular system have been intertwined over the past one-half century. This is true of bioengineering as an area for research in universities. Bioengineering is ultimately the beginning of a new engineering discipline, as well as a new discipline in the medical device industry.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
In vitro images of morphology and F-actin for bovine aortic endothelial cells for static conditions (A and B) and after 24 hours of laminar shear stress (C and D) with flow left to right; scale of F-actin images a factor of ten different from the morphology images.
Figure 2.
Figure 2.
Illustration of difference in the hemodynamic environment for the fibrosa side versus the ventricularis side of the aortic heart valve and the influence on calcification and sclerosis.
See this image and copyright information in PMC

References

    1. Citron P, Nerem RM. Bioengineering: 25 years of progress, but still only a beginning. Technol Soc. 2004;26(2–3):415–431.
    1. Bergman RM, Nerem RM. The cardiovascular technology industry: past, present, and future. Cardiovasc Eng Technol. 2010;1(1):19–24.
    1. Davies PF. Hemodynamic shear stress and the endothelium in cardiovascular pathophysiology. Nat Clin Pract Cardiovasc Med. 2009;6:16. - PMC - PubMed
    1. Levesque MJ, Nerem RM. The elongation and orientation of cultured endothelial cells in response to shear stress. ASME J Biomech Eng. 1985;107(4):341–347. - PubMed
    1. Dewey CF, Jr, Bussolari SR, Gimbrone MA, Jr, Davies PF. The dynamic response of vascular endothelial cells to fluid shear stress. ASME J Biomech Eng. 1981;103:177–185. - PubMed

LinkOut - more resources