Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2014 Apr 1;9(4):e93437.
doi: 10.1371/journal.pone.0093437. eCollection 2014.

Dietary mushroom intake may reduce the risk of breast cancer: evidence from a meta-analysis of observational studies

Jiaoyuan Li  1 , Li Zou  1 , Wei Chen  1 , Beibei Zhu  1 , Na Shen  1 , Juntao Ke  1 , Jiao Lou  1 , Ranran Song  1 , Rong Zhong  1 , Xiaoping Miao  1
Affiliations
Meta-Analysis

Dietary mushroom intake may reduce the risk of breast cancer: evidence from a meta-analysis of observational studies

Jiaoyuan Li et al. PLoS One. .

Abstract

Epidemiological studies have investigated the potential anticancer effects of mushroom intake. This review aims to clarify the evidence on the association of dietary mushroom intake with breast cancer risk and to quantify its dose-response relationship. Relevant studies were identified by a search of PubMed, Web of Science and Google Scholar up to December 31, 2013. Observational studies with relative risks (RRs) or hazard ratios (HRs) or odd ratios (ORs) and 95% confidence intervals (CIs) of breast cancer for three or more categories of mushroom intake were eligible. The quality of included studies was assessed by using Newcastle-Ottawa Scale. A dose-response meta-analysis was performed by utilizing generalized least squares trend estimation. Eight case-control studies and two cohort studies with a total of 6890 cases were ultimately included. For dose-response analysis, there was no evidence of non-linear association between mushroom consumption and breast cancer risk (P = 0.337) and a 1 g/d increment in mushroom intake conferred an RR of 0.97 (95% CI: 0.96-0.98) for breast cancer risk, with moderate heterogeneity (I(2) = 56.3%, P = 0.015). Besides, available menopause data extracted from included studies were used to evaluate the influence of menopausal statues. The summary RRs of mushroom consumption on breast cancer were 0.96 (95% CI: 0.91-1.00) for premenopausal women and 0.94 (95% CI: 0.91-0.97) for postmenopausal women, respectively. Our findings demonstrated that mushroom intake may be inversely associated with risk of breast cancer, which need to be confirmed with large-scale prospective studies further.

PubMed Disclaimer

Conflict of interest statement

Competing Interests: The corresponding author of this manuscript, Xiaoping Miao, is a PLOS ONE Editorial Board member. This does not alter our adherence to PLOS ONE Editorial policies and criteria.

Figures

Figure 1
Figure 1. Flow chart of articles' selection.
Figure 2
Figure 2. The dose-response analysis for the association of mushroom consumption and breast cancer risk, with restricted cubic splines in random-effects dose-response model.
The solid line and the short dash line represent the estimated relative risks and corresponding 95% CIs, respectively.
Figure 3
Figure 3. Study-specific dose-response analyses for the relationship between mushroom consumption and risk of breast cancer.
Figure 4
Figure 4. Dose-response meta-analyses for premenopausal and postmenopausal women.
Figure 5
Figure 5. Publication bias in the studies.
See this image and copyright information in PMC

References

    1. Jemal A, Bray F (2011) Center MM, Ferlay J, Ward E, et al (2011) Global cancer statistics. CA Cancer J Clin 61: 69–90. - PubMed
    1. Key TJ, Verkasalo PK, Banks E (2001) Epidemiology of breast cancer. Lancet Oncol 2: 133–140. - PubMed
    1. Hirose K, Tajima K, Hamajima N, Inoue M, Takezaki T, et al. (1995) A large-scale, hospital-based case-control study of risk factors of breast cancer according to menopausal status. Jpn J Cancer Res 86: 146–154. - PMC - PubMed
    1. Lee HP, Gourley L, Duffy SW, Estève J, Lee J, et al. (1992) Risk factors for breast cancer by age and menopausal status: a case-control study in Singapore. Cancer Causes Control 3: 313–322. - PubMed
    1. Goss PE, Strasser K (2001) Aromatase inhibitors in the treatment and prevention of breast cancer. J Clin Oncol 19: 881–894. - PubMed

Publication types