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. 1989 Apr 24;247(2):349-52.
doi: 10.1016/0014-5793(89)81368-7.

Inhibition of HIV replication in cell culture by the specific aspartic protease inhibitor pepstatin A

K von der Helm  1 , L Gürtler, J Eberle, F Deinhardt
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Free article

Inhibition of HIV replication in cell culture by the specific aspartic protease inhibitor pepstatin A

K von der Helm et al. FEBS Lett. .
Free article

Abstract

After incubation of H9 cells infected with human immunodeficiency virus (HIV) with pepstatin A at 10(-4) M for 2, 4, or 11 days, the culture medium contained significantly less HIV core antigen (p24) than controls without pepstatin A and no or only borderline activity of reverse transcriptase was detected. In addition, after pepstatin A treatment no infectious HIV at 2 or 4 days and only minimal amounts at 11 days were detectable in the culture medium.

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