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. 2014 Jan;10(37):61-5.
doi: 10.4103/0973-1296.126663.

Curcumin attenuates neurotoxicity induced by fluoride: An in vivo evidence

Chhavi Sharma  1 , Pooja Suhalka  1 , Piyu Sukhwal  1 , Neha Jaiswal  1 , Maheep Bhatnagar  1
Affiliations

Curcumin attenuates neurotoxicity induced by fluoride: An in vivo evidence

Chhavi Sharma et al. Pharmacogn Mag. 2014 Jan.

Abstract

Background: Curcumin (Cur), an active ingredient of turmeric is known to have multiple activities, including an antioxidant property and has been suggested to be useful in treatment of several neurological diseases.

Objective: To investigate the neuroprotective effects of Cur to mitigate the effect of the Fluoride (F) induced neurotoxicity in mice brain using the histological and the biochemical parameters.

Materials and methods: Exposure of mice (30 days old male) to F (120 ppm) daily for 30 days.

Result and discussion: Treatment with the F causes an increase in lipid peroxidation (LPO) and also increase in the neurodegenerative cells in the hippocampal sub-regions. Interestingly, co-treatment with Cur (30 mg/kg BW) with F (120 ppm) for 30 days results in significant decreases in LPO with a concomitant decrease in neurodegeneration as compared with those treated with F alone.

Conclusion: Our study reveals that Cur is useful in ameliorating degenerative effects of F in mice brain.

Keywords: Curcumin; fluoride; histology.; lipid peroxidation; neurodegeneration; neuroprotection; oxidative stress.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Effect of Fluoride (F) and Curcumin (Cur) on Malondialdehyde content of mice Brain. Data represented as mean ± SD, P < 0.001**, no sign = non-significant. On comparing control to Group F (**a) and F+ Cur (**b); F to Group F + Cur (**b) and Cur (**c)
Figure 2
Figure 2
Effect of Fluoride (F) and Curcumin (Cur) on Neuronal viability. Data represented as Mean ± SE (P < 0.05)**, No sign = No significance. On comparing control to F Group (**a) and F + Cur (**b); F Group to F + Cur (**b) and Cur (**C)
Figure 3
Figure 3
Photomicrographs demonstrating (Cornu Ammonis) CA1, CA3 and Dentate gyrus region of Hippocampus showing Cresyl violet staining in Control, 120 ppm fluoride (F), Curcumin (Cur) and F + Cur treated group
See this image and copyright information in PMC

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