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Editorial

. 2014;13(9):1366-7.

doi: 10.4161/cc.28751. Epub 2014 Apr 3.

Crosstalk between the Arg/N-end and Ac/N-end rule

Jeong-Mok Kim¹, Cheol-Sang Hwang¹

Affiliations

PMID: 24698805
PMCID: PMC4050130
DOI: 10.4161/cc.28751

Editorial

Crosstalk between the Arg/N-end and Ac/N-end rule

Jeong-Mok Kim et al. Cell Cycle. 2014.

. 2014;13(9):1366-7.

doi: 10.4161/cc.28751. Epub 2014 Apr 3.

Authors

Jeong-Mok Kim¹, Cheol-Sang Hwang¹

Affiliation

¹ Department of Life Sciences; Pohang University of Science and Technology; Pohang, Gyeongbuk, South Korea.

PMID: 24698805
PMCID: PMC4050130
DOI: 10.4161/cc.28751

No abstract available

Keywords: N-end rule; Ubr1; acetylation; degron; methionine; proteolysis; ubiquitin.

PubMed Disclaimer

Figures

None — Figure 1. Crosstalk between the Arg/N-end rule pathway and the Ac/N-end rule pathway. Nearly all nascent proteins bear N-terminal Met due to the AUG start codon. The Arg/N-end rule pathway targets for degradation proteins with unacetylated N-terminal Met if it is followed by a large hydrophobic Ф residue (Leu, Ile, Phe, Tyr, Trp) at position 2. Nt-acetylase catalyzes Nt-acetylation of the Met-Ф proteins either cotranslationally or posttranslationally, and thereby creates the Ac/Met-Ф degrons for the Ac/N-end rule pathway.

See this image and copyright information in PMC

Comment on

The N-terminal methionine of cellular proteins as a degradation signal.
Kim HK, Kim RR, Oh JH, Cho H, Varshavsky A, Hwang CS. Kim HK, et al. Cell. 2014 Jan 16;156(1-2):158-69. doi: 10.1016/j.cell.2013.11.031. Epub 2013 Dec 19. Cell. 2014. PMID: 24361105 Free PMC article.

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References

1. Ravid T, et al. Nat Rev Mol Cell Biol. 2008;9:679–90. doi: 10.1038/nrm2468. - DOI - PMC - PubMed
1. Bachmair A, et al. Science. 1986;234:179–86. doi: 10.1126/science.3018930. - DOI - PubMed
1. Varshavsky A. Protein Sci. 2011;20:1298–345. doi: 10.1002/pro.666. - DOI - PMC - PubMed
1. Sriram SM, et al. Nat Rev Mol Cell Biol. 2011;12:735–47. doi: 10.1038/nrm3217. - DOI - PubMed
1. Starheim KK, et al. Trends Biochem Sci. 2012;37:152–61. doi: 10.1016/j.tibs.2012.02.003. - DOI - PubMed

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