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Editorial
. 2014;13(9):1366-7.
doi: 10.4161/cc.28751. Epub 2014 Apr 3.

Crosstalk between the Arg/N-end and Ac/N-end rule

Jeong-Mok Kim  1 , Cheol-Sang Hwang  1
Affiliations
Editorial

Crosstalk between the Arg/N-end and Ac/N-end rule

Jeong-Mok Kim et al. Cell Cycle. 2014.
No abstract available

Keywords: N-end rule; Ubr1; acetylation; degron; methionine; proteolysis; ubiquitin.

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Figures

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Figure 1. Crosstalk between the Arg/N-end rule pathway and the Ac/N-end rule pathway. Nearly all nascent proteins bear N-terminal Met due to the AUG start codon. The Arg/N-end rule pathway targets for degradation proteins with unacetylated N-terminal Met if it is followed by a large hydrophobic Ф residue (Leu, Ile, Phe, Tyr, Trp) at position 2. Nt-acetylase catalyzes Nt-acetylation of the Met-Ф proteins either cotranslationally or posttranslationally, and thereby creates the Ac/Met-Ф degrons for the Ac/N-end rule pathway.
See this image and copyright information in PMC

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References

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