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Comparative Study
. 2014 Apr 3;9(4):e89639.
doi: 10.1371/journal.pone.0089639. eCollection 2014.

Temporary treatment during primary HIV infection does not affect virologic response to subsequent long-term treatment

Marlous L Grijsen  1 , Ferdinand W N M Wit  2 , Suzanne Jurriaans  3 , Frank P Kroon  4 , Emile F Schippers  5 , Peter Koopmans  6 , Luuk Gras  7 , Joep M A Lange  2 , Jan M Prins  1 ; Primo-SHM Study Group
Collaborators, Affiliations
Comparative Study

Temporary treatment during primary HIV infection does not affect virologic response to subsequent long-term treatment

Marlous L Grijsen et al. PLoS One. .

Abstract

Temporary cART during primary HIV-infection (PHI) did not select for drug resistance mutations after treatment interruption and did not affect the subsequent virological response to long-term cART. Our data demonstrate that fear of drug resistance development is not a valid argument to refrain from temporary early treatment during PHI.

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Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Viral decay after treatment (re)initiation of long-term cART in naive and early treated patients.
Figure 2
Figure 2. Proportion of patients with an undetectable pVL after (re)initiation of long-term cART over a period of 144 weeks in naive and early treated patients.
Figure 3
Figure 3. CD4 count recovery after treatment (re)initiation of long-term cART in naive and early treated patients.
Figure 4
Figure 4. Viral decay after treatment initiation of early cART and subsequent long-term cART in the early treated patients.
See this image and copyright information in PMC

References

    1. Grijsen ML, Steingrover R, Wit FW, Jurriaans S, Verbon A, et al. (2012) No Treatment versus 24 or 60 Weeks of Antiretroviral Treatment during Primary HIV Infection: The Randomized Primo-SHM Trial. PLoS Med 9 ((3)) e1001196. - PMC - PubMed
    1. Hogan CM, Degruttola V, Sun X, Fiscus SA, Del RC, et al. (2012) The setpoint study (ACTG A5217): effect of immediate versus deferred antiretroviral therapy on virologic set point in recently HIV-1-infected individuals. J Infect Dis 205: 87–96. - PMC - PubMed
    1. Fidler S, Porter K, Ewings F, Frater J, Ramjee G, et al. (2013) Short-Course Antiretroviral Therapy in Primary HIV Infection. N Engl J Med 368: 207–217. - PMC - PubMed
    1. Fidler S, Oxenius A, Brady M, Clarke J, Cropley I, et al. (2002) Virological and immunological effects of short-course antiretroviral therapy in primary HIV infection. AIDS 16: 2049–2054. - PubMed
    1. Taylor S, Boffito M, Khoo S, Smit E, Back D (2007) Stopping antiretroviral therapy. AIDS 21: 1673–1682. - PubMed

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