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. 2014:2014:641685.
doi: 10.1155/2014/641685. Epub 2014 Feb 19.

Preoperative gadoxetic Acid-enhanced MRI and simultaneous treatment of early hepatocellular carcinoma prolonged recurrence-free survival of progressed hepatocellular carcinoma patients after hepatic resection

Masanori Matsuda  1 , Tomoaki Ichikawa  2 , Hidetake Amemiya  1 , Akira Maki  1 , Mitsuaki Watanabe  1 , Hiromichi Kawaida  1 , Hiroshi Kono  1 , Katsuhiro Sano  2 , Utaroh Motosugi  2 , Hideki Fujii  1
Affiliations

Preoperative gadoxetic Acid-enhanced MRI and simultaneous treatment of early hepatocellular carcinoma prolonged recurrence-free survival of progressed hepatocellular carcinoma patients after hepatic resection

Masanori Matsuda et al. HPB Surg. 2014.

Abstract

Background/Purpose. The purpose of this study was to clarify whether preoperative gadoxetic acid-enhanced magnetic resonance imaging (EOB-MRI) and simultaneous treatment of suspected early hepatocellular carcinoma (eHCC) at the time of resection for progressed HCC affected patient prognosis following hepatic resection. Methods. A total of 147 consecutive patients who underwent their first curative hepatic resection for progressed HCC were enrolled. Of these, 77 patients underwent EOB-MRI (EOB-MRI (+)) before hepatic resection and the remaining 70 patients did not (EOB-MRI (-)). Suspected eHCCs detected by preoperative imaging were resected or ablated at the time of resection for progressed HCC. Results. The number of patients who underwent treatment for eHCCs was significantly higher in the EOB-MRI (+) than in the EOB-MRI (-) (17 versus 6; P = 0.04). Recurrence-free survival (1-, 3-, and 5-year; 81.4, 62.6, 48.7% versus 82.1, 41.5, 25.5%, resp., P < 0.01), but not overall survival (1-, 3-, and 5-year; 98.7, 90.7, 80.8% versus 97.0, 86.3, 72.4%, resp., P = 0.38), was significantly better in the EOB-MRI (+). Univariate and multivariate analyses showed that preoperative EOB-MRI was one of the independent factors significantly correlated with better recurrence-free survival. Conclusions. Preoperative EOB-MRI and simultaneous treatment of eHCC prolonged recurrence-free survival after hepatic resection.

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Figures

Figure 1
Figure 1
Overall survival curves of patients stratified according to the presence or absence of preoperative EOB-MRI after hepatic resection for progressed HCC.
Figure 2
Figure 2
Recurrence-free survival curves of patients stratified according to the presence or absence of preoperative EOB-MRI after hepatic resection for progressed HCC.
See this image and copyright information in PMC

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