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Case Reports
. 2014 Mar;24(2):114-6.
doi: 10.4103/0971-4065.127902.

Mesangial proliferative glomerulonephritis with acute tubule interstitial nephritis leading to acute kidney injury in influenza A (H1N1) infection

V B Kute  1 , A V Vanikar  2 , P R Shah  1 , M R Gumber  1 , H V Patel  1 , H L Trivedi  1
Affiliations
Case Reports

Mesangial proliferative glomerulonephritis with acute tubule interstitial nephritis leading to acute kidney injury in influenza A (H1N1) infection

V B Kute et al. Indian J Nephrol. 2014 Mar.

Abstract

Respiratory complications and renal failure are the leading causes for morbidity and mortality due to influenza (H1N1) virus infection. There has been limited information on histopathology of H1N1 influenza-related acute kidney injury (AKI). We describe AKI with H1N1 infection in a 52-year-old female. Renal biopsy showed mesangial proliferative glomerulonephritis with acute tubule interstitial nephritis. Her condition improved rapidly with oseltamivir, fluid replacement, steroid and dialysis. Our case suggests that H1N1 infection may have a causative link to the development of mesangial proliferative glomerulonephritis with acute tubulointerstitial nephritis.

Keywords: Acute kidney injury; H1N1 influenza; glomerulonephritis; histopathology.

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Conflict of interest statement

Conflict of Interest: None declared.

Figures

Figure 1
Figure 1
Renal biopsy (H and E, ×400) revealed mesangial proliferative glomerulonephritis with acute tubule interstitial nephritis
See this image and copyright information in PMC

References

    1. Demirjian SG, Raina R, Bhimraj A, Navaneethan SD, Gordon SM, Schreiber MJ, Jr, et al. 2009 influenza A infection and acute kidney injury: Incidence, risk factors, and complications. Am J Nephrol. 2011;34:1–8. - PubMed
    1. Watanabe T. Renal complications of seasonal and pandemic influenza A virus infections. Eur J Pediatr. 2013;172:15–22. - PubMed
    1. Shelke VN, Kolhapure RM, Kadam D, Sangle S, Chadha MC, Basu A, et al. Pathologic study of pandemic influenza A (H1N1) 2009 cases from India. Pathol Int. 2012;62:36–42. - PubMed
    1. Perez-Padilla R, de la Rosa-Zamboni D, Ponce de Leon S, Hernandez M, Quiñones-Falconi F, Bautista E, et al. Pneumonia and respiratory failure from swine-origin influenza A (H1N1) in Mexico. N Engl J Med. 2009;361:680–9. - PubMed
    1. Sood MM, Rigatto C, Zarychanski R, Komenda P, Sood AR, Bueti J, et al. Acute kidney injury in critically ill patients infected with 2009 pandemic influenza A (H1N1): Report from a Canadian province. Am J Kidney Dis. 2010;55:848–55. - PMC - PubMed

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