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. 2014 Feb 15;4(1):e14129.
doi: 10.5812/aapm.14129. eCollection 2014 Feb.

Effect of intravenous patient controlled ketamine analgesiaon postoperative pain in opium abusers

Mastane Dahi-Taleghani  1 , Benjamin Fazli  1 , Mahshid Ghasemi  1 , Maryam Vosoughian  1 , Ali Dabbagh  1
Affiliations

Effect of intravenous patient controlled ketamine analgesiaon postoperative pain in opium abusers

Mastane Dahi-Taleghani et al. Anesth Pain Med. .

Abstract

Background: Acutepostoperative pain is among the worst experience that patient scan undergo, and many analgesics have been used to suppress it; especially in chronic opium abusers. Ketamine is an N-methyl-D-aspartate antagonist analgesic, having both anesthetic and analgesic properties, which are not affected to the same extent in chronic opium abusers.

Objectives: In this study, we assessed the analgesic effects of ketamine added to morphine as a patient-controlled analgesia method for acute pain management, compared with a placebo, inchronic maleopium abusers.

Patients and methods: After institutional review board approval for ethical considerations, a randomized double-blinded placebo controlled clinical trial was conducted. A total of 140 male patients aged 18-65 years, undergoing orthopedic surgery, were entered into the study after matching inclusion and exclusion criteria. All patients received the same anesthesia method; while the first group received ketamine (1mg/mL) and morphine (0.5 mg/mL) as a patient-controlled analgesia (70 patients), the second group received morphine (0.5 mg/mL) plus normal saline (70 patients). P value less than 0.05 was considered statistically significant.

Results: The ketamine and morphine group of patients experienced less postoperative pain and required less postoperative rescue analgesia. However, the unwanted postoperative side effects were nearly the same; although increased levels of postoperative nausea and vomiting were observed in the ketamine and morphine group.

Conclusions: This study demonstrated improved analgesic effects after using intravenous patient controlled analgesia with ketamine on postoperative pain in opium abusers.

Keywords: Acute Pain; Drug Users; Ketamine; Opium.

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Figures

Figure 1.
Figure 1.. Summary of the Study Stages are Presented in the Diagram
See this image and copyright information in PMC

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