Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2014 Feb;8(2):147-8.
doi: 10.7860/JCDR/2014/6811.4036. Epub 2014 Feb 3.

Small cell neuroendocrine carcinoma of the cervix: a rare entity

Pavithra V  1 , C N Sai Shalini  1 , Shanmuga Priya  1 , Usha Rani  2 , S Rajendiran  3 , Leena Dennis Joseph  3
Affiliations
Case Reports

Small cell neuroendocrine carcinoma of the cervix: a rare entity

Pavithra V et al. J Clin Diagn Res. 2014 Feb.

Abstract

Small cell carcinoma of the cervix is a rare and a very aggressive tumour. Once being considered to be a rare type of squamous cell carcinoma, evidence has proven that most of the tumours express one or more markers of neuroendocrine differentiation. The behaviour of this rare malignancy is different from that of squamous cell carcinomas, with a high propensity for nodal and distant metastases. Hence, there is a need to highlight this histopathological entity.

Keywords: Cervix; Neuroendocrine; Small cell.

PubMed Disclaimer

Figures

[Table/Fig-1]:
[Table/Fig-1]:
Cervix – Small round blue cells (H&E 200x)
[Table/Fig-2]:
[Table/Fig-2]:
Cervix –Small round blue cells (H&E 400x)
[Table/Fig-3]:
[Table/Fig-3]:
Cervix-Cytokeratin positivity (IHC 200x)
[Table/Fig-4]:
[Table/Fig-4]:
Cervix-Synaptophysin positivity (IHC 200x)
[Table/Fig-5]:
[Table/Fig-5]:
Cervix – CD 45 negativity (IHC 200x)
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. F Fetissof, MP Dubois, PU Heitz. Endocrine cells in the female genital tract. International Journal of Gynaecological Pathology. 1986;5:75–87. - PubMed
    1. Eichhorn John H, Young Robert H. Neuroendocrine tumors of the genital tract pathology and patterns review. American. Journal of Clinical Pathology. 2001;115:94–112. - PubMed
    1. RA Ambros, J Park, ShahK Evaluation of histologic, morphometric, and immunohistochemical criteria in the differential diagnosis of small cell carcinoma of the cervix with particular reference to human papilloma virus types 16 and 18. Modern Pathology. 1991;4:586–93. - PubMed
    1. MH Stoler, SE Mills, DJ Gersell. Small cell neuroendocrine carcinoma of the cervix: a human papillomavirus type 18-associated cancer. Am J Surg Pathol. 1991;15:28–32. - PubMed
    1. EE Sheets, ML Berman, CK Hrountas. Surgically treated early-stage neuroendocrine small-cell cervical carcinoma. Obstet and Gynecol. 1988;71:10–14. - PubMed

Publication types

LinkOut - more resources