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Comment
. 2014 May;71(5):387-90.
doi: 10.1111/aji.12243. Epub 2014 Apr 7.

New insights into the relationship between viral infection and pregnancy complications

Ja-Young Kwon  1 , Roberto Romero, Gil Mor
Affiliations
Comment

New insights into the relationship between viral infection and pregnancy complications

Ja-Young Kwon et al. Am J Reprod Immunol. 2014 May.

Abstract

A recent study by McDonnold and coinvestigators published in Am J Obstet Gynecol reports an association between human papillomavirus (HPV) infection and preeclampsia. The investigation was based on the hypothesis that HPV trophoblast infection results in failed trophoblast invasion, and placental dysfunction and hypoxia. The findings from this study along with previous data addressing the relationship between viral infection and obstetrical complications highlight the relevance of viral infection during pregnancy. A better understanding of mechanisms via which virus leads to pregnancy complications will drive us closer to finding a strategy to prevent adverse outcomes.

Keywords: Complication; infection; pregnancy; virus.

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Conflict of interest statement

Disclosure: The authors report no conflicts of interest.

Figures

Figure 1
Figure 1
Potential effect of viral infection on trophoblast function leading to pregnancy complications. HPV, human papilloma virus; IUGR, intrauterine growth restriction; PE, preeclampsia.
See this image and copyright information in PMC

Comment on

References

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