Antifertility activity of Artemisia vulgaris leaves on female Wistar rats
- PMID: 24702803
- DOI: 10.1016/S1875-5364(14)60030-3
Antifertility activity of Artemisia vulgaris leaves on female Wistar rats
Abstract
Aim: To evaluate the antifertility activity of Artemisia vulgaris leaves on female Wistar rats.
Method: The plant extract was tested for its effect on implant formation at two dose levels, 300 and 600 mg·kg⁻¹, respectively. The effective methanolic plant extract was further studied for estrogenic potency on ovariectomised immature female Wistar rats.
Results: The data presented in this study demonstrate the antifertility potential of Artemisia vulgaris methanolic leaf extract, which shows a strong and significant decrease in implant formation (100%), and a strong estrogenic effect resulting in a significant increase in uterine weight in immature ovariectomised rats. These observations suggest that the methanolic extract of Artemisia vulgaris leaves has strong anti-implantation activity and estrogenic activity.
Conclusion: The methanolic plant extract of A. vulgaris has antifertility activity.
Keywords: Anti-implantation activity; Antifertility activity; Artemisia vulgaris; Estrogenic activity.
Copyright © 2014 China Pharmaceutical University. Published by Elsevier B.V. All rights reserved.
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