How Tets and cytoskeleton dynamics MET in reprogramming
- PMID: 24702989
- DOI: 10.1016/j.stem.2014.03.007
How Tets and cytoskeleton dynamics MET in reprogramming
Abstract
Two studies by Sakurai et al. (2014) and Hu et al. (2014) in this issue of Cell Stem Cell add a new level of understanding to the mesenchymal-to-epithelial transition taking place during reprogramming, showing how this morphological transformation is promoted by Tet enzymes and blocked by kinase-dependent cytoskeletal organization.
Copyright © 2014 Elsevier Inc. All rights reserved.
Comment on
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Tet and TDG mediate DNA demethylation essential for mesenchymal-to-epithelial transition in somatic cell reprogramming.Cell Stem Cell. 2014 Apr 3;14(4):512-22. doi: 10.1016/j.stem.2014.01.001. Epub 2014 Feb 13. Cell Stem Cell. 2014. PMID: 24529596
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Kinome-wide functional analysis highlights the role of cytoskeletal remodeling in somatic cell reprogramming.Cell Stem Cell. 2014 Apr 3;14(4):523-34. doi: 10.1016/j.stem.2014.03.001. Cell Stem Cell. 2014. PMID: 24702998 Free PMC article.
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