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Comment
. 2014 Apr 3;14(4):421-2.
doi: 10.1016/j.stem.2014.03.008.

On the origin of leukemic species

Aparna Vasanthakumar  1 , Lucy A Godley  2
Affiliations
Free article
Comment

On the origin of leukemic species

Aparna Vasanthakumar et al. Cell Stem Cell. .
Free article

Abstract

Recent studies (Shlush et al., 2014; Corces-Zimmerman et al., 2014) have demonstrated that leukemias develop from hematopoietic stem cells that acquire preleukemic mutations, allowing clonal expansion and subsequent acquisition of mutations leading to cancer. Preleukemic cells survive chemotherapy and serve as reservoirs for disease, generating new clones and leading to relapse.

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